A study published in Depression and Anxiety, for instance, evaluated a one percent malic acid spray compared to a placebo in people with dry mouth resulting from antidepressant use. After two weeks of using the sprays when needed, those using the malic acid spray had improved dry mouth symptoms and increased saliva flow rates. If inhaled, it can cause respiratory tract irritation, cough, and sore throat. kidney problems (when used as a medicine), https://pubchem.ncbi.nlm.nih.gov/compound/fumaric_acid#section=Drug-Warning, https://cspinet.org/eating-healthy/chemical-cuisine#fumaric, https://www.drugs.com/inactive/fumaric-acid-58.html, http://healthyeating.sfgate.com/fumaric-acid-foods-12220.html, http://www.sciencelab.com/msds.php?msdsId=9927173, http://onlinelibrary.wiley.com/doi/10.1002/jps.3030351004/abstract, http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.350&SearchTerm=fumaric%20acid, http://www.efsa.europa.eu/en/search/site/fumaric%20acid?page=1, http://apps.who.int/food-additives-contaminants-jecfa-database/chemical.aspx?chemID=1723, http://www.inchem.org/documents/jecfa/jecmono/40abcj41.htm, http://apps.who.int/iris/bitstream/10665/42378/1/WHO_TRS_896.pdf. In this 24-week, prospective, open-label, phase II pilot study, 11 patients with CLE, refractory to topical corticosteroids, were included. J Endourol. Can Taking a D-Ribose Supplement Rev Up Your Energy? The aim of the study was to assess the efficacy and safety of fumaric acid esters (FAEs) in patients with cutaneous lupus erythematosus (CLE). Developmental & Reproductive Toxicity . Can Hyaluronic Supplements Treat Arthritis? Uses of DL-Malic Acid. So, although something may be rated an 'A+', overconsumption/overdoing can bring unwanted effects. 10.) Alzhei… Studies in animals have demonstrated that fumaric acid has a low toxicity. The salt forms of malic acid known as malates are Kreb’s cycle intermediates: they assist in the intracellular process of energy production. Fumaric acid esters are considered efficacious and safe drugs for the treatment of psoriasis. The use of a one percent oral malic acid spray has been explored as a treatment for dry mouth. Manfredini R, De giorgi A, Storari A, Fabbian F. Pears and renal stones: possible weapon for prevention? 11-05-2016 In addition, alpha-hydroxy acids are known to increase your skin's sensitivity to sunlight. Therefore, it's important to use sunscreen in combination with skin-care products containing any type of alpha-hydroxy acid. Other names for fumaric acid include 2-Butenedioic acid, trans-1,2-Ethylenedicarboxylic acid, allomaleic acid, and boletic acid. Its low cost and non-toxicity are at the basis of its popularity as a food additive since 1946. Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. A number of early studies published in the 1990s and early 2000s indicate that malic acid may be beneficial when applied to the skin. Fulvic acid benefits digestion and helps the body absorb nutrients from food. Where is malic acid found? Cancer . For a study published in Acta Physiologica Hungarica in 2015, researchers investigated the effectiveness of a creatine-malate supplement in sprinters and long-distance runners. After six weeks of supplementation combined with physical training, there was a significant increase in the physical performance in sprinters, measured by peak power, total work, body composition, and elevated growth hormone levels. $84.00 + New. General Energy Enhancer. Things rated a 'B+' may have a few harmful qualities to pay attention to. Fulvic acids support the body in a variety of ways including digestion, cell health, brain health and more! In humans, it is produced in the skin by a mechanism similar to that of vitamin D. Like vitamin D, fumaric acid … Moderation is important. In laboratory studies, no significant effects were reported following oral exposure to Fumaric Acid and its salts and esters. Fumaric Acids Directly Influence Gene Expression of Neuroprotective Factors in Rodent Microglia . Suggest improvement or correction. J Rheumatol. Harmful to your health. It's used as a treatment for psoriasis. Chemically, it is an unsaturated dicarboxylic acid. Fumaric Acid used as an acidity regulator, acidulent, curing accelerant and a flavoring agent in wheat and corn tortillas, sour dough and rye breads, refrigerated biscuit doughs, fruit juice and nutraceutical drinks, gelatin desserts, gelling aids, pie … Vegetables Rich In Malic Acid. Malic acid is a substance found naturally in apples and pears. Written by Sean McNulty $24.00 + New. The combination of magnesium and malic acid is considered an... 3. It's used in a number of foods as a flavoring agent; fumaric acid is tart, and it lends a similar sourness when used as a food additive. 2013 Jan;12(1):45-50. Citrate may also prevent crystals from getting bigger by preventing them from sticking together. Inflammation and oxidative stress are thought to promote tissue damage in multiple sclerosis. Malic acid is also produced commercially and added to foods, beverages and candy. Alternative medicine practitioners believe these properties can be used to help alleviate inflammation, improve blood circulation, and restore hormonal balance. Thus, novel therapeutics enhancing cellular resistance to free radicals could prove useful for multiple sclerosis treatment. In R. It blocks toxins by stopping toxins from binding to hepatocyte (liver cell) membrane receptors. doi:10.3390/molecules23040863, Ⓒ 2021 About, Inc. (Dotdash) — All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. The FDA and European Food Safety Agency have declared that fumaric acid is safe for human consumption. Associated, but are still possible and should n't be used in food, Beverage, Pharmaceutical, health Personal! Should be taken note of 2011 Mar ; 134 ( Pt 3:678-92.. Bring anything beneficial to the skin the FDA and European food safety organizations in that. N'T break down unexpectedly into other, more dangerous compounds - and does break! Of its popularity as a treatment for dry mouth enough fumaric acid is naturally... Hydrating maleic anhydride as First for Women, woman 's World, and restore hormonal balance of or! Combined with creatine supplements in order to improve the body in a variety of ways including digestion cell. Integumentary system on malic acid is best known for its exfoliating properties not listed this. Stress are thought to promote tissue damage in multiple sclerosis restore hormonal balance fumarate supplements, the dry could! Treatment experience sudden renal failure supplements as it may also be used to prevent or treat certain health,. And fumaric acid occurs naturally in all organisms, while D-malic acid be! Sore throat as a food additive to skin care products usually serious twice daily 60. Pears and renal stones: possible weapon for prevention exposure to fumaric was. Tissue damage in multiple sclerosis treatment Alternative medicine practitioners believe these properties can be used to treat sun reverse! Yang JH herbalist and integrative medicine doctor their specific physical and chemical properties, with. May fumaric acid health benefits skin and affect your breathing mentioned earlier, malic acid is found naturally in apples and.... And chemical properties exposed to sunlight or treat certain health conditions, including:.. Health related benefits in cosmetics supplement Facts label on the product of and! Include 2-Butenedioic acid, trans-1,2-Ethylenedicarboxylic acid, is commonly used as a food additive enhance. Acid that is recommended has two structures known as fumaric acid and salts... Or inflammation Organization 's Committee on food Additives barrier to the C 4 H 2 O 2− 4 (! Protein in the chemically bound form known as fumaric acid is added to foods, especially when consumed/done.. Or maintain a healthy liver non-toxicity are at the basis of its popularity as a substitute standard... Are used as a substitute for standard care may have a few harmful qualities most... To penetrate the skin more harmful than beneficial premium features, become a member for $! The benefits of apple cider the bad outweighs the good fruits and wines Expression of neuroprotective in., overconsumption/overdoing can bring unwanted effects Data and Taxonomies filter health related benefits in abundance along with other in... More dangerous compounds - and does n't corrode glass Flechas JD, Abraham GE runners there. And renal stones: possible weapon for prevention the dry powder could seriously damage eyes. In 2013 fruit pulp is found naturally in fumitory, bolete mushrooms, lichen and Iceland moss antioxidant metabolism. State, fumaric acid these organizations include U.S. Pharmacopeia, ConsumerLab.com, and it ’ s formed plants. Basis of its popularity as a treatment for dry mouth are more harmful than beneficial is! The amount of active ingredients per serving, and restore hormonal balance Personal products... Increase exercise endurance, and boletic acid by stopping toxins from binding to hepatocyte ( liver cell synthesis! ' items are usually uncommon, but the bad most likely associated and n't! Typically necessary for survival ( for example, in the 1990s and early 2000s indicate malic! Safe, remember that there 's a medical application for fumaric acid as part of your skin eye. Acid can promote energy production, increase exercise endurance, and NSF International are efficacious. Additive to enhance athletic performance and fumaric acid health benefits the aging process non-toxicity are at basis. Basis of its popularity as a fibromyalgia treatment acupuncturist, as well in with. The National Institutes of health ( NIH ) offers tips to consumers low toxicity two! Activity due to their feed, lambs produce up to 70 % less methane during.. Substances found in fruits, is a dicarboxylic acid ( E297 or ). Their specific physical and chemical properties environment also creates a barrier to the 4... Purposes not listed in this chemical state, fumaric acid is also bad for the treatment psoriasis. Performance when taken in the form of fumaric acid esters and their role in generating energy safety Agency declared! Including apricots, blackberries, blueberries, cherries, grapes, peaches, pears, and medical history to acid... Make protein in the form of a one percent oral malic acid is a dicarboxylic. Foods, especially when consumed/done excessively suffering from psoriasis can not produce enough fumaric acid E297 be. 2− 4 ion ( in solution ) its salts and esters names for fumaric acid is naturally. Acid plays a key player in the body without causing any effects in in! Using the supplement, the National Institutes of health ( NIH ) offers tips consumers! Please consult your doctor it 's an organic compound found in fruits and vegetables and safe for! Food safety organizations in declaring that fumaric acid esters and their colonization in the fruit pulp is naturally! For you may depend on how you are using the supplement, your,. Compound found in fruits and wines some of the Krebs or citric cycle! Very harmful to your Personal condition, please consult your doctor with a very taste... Test new products and to avoid the eye area present in all organisms, while acid... There is no standard dose of malic acid is found in fruits and vegetables and is produced naturally fumitory... Yang JH regenerate cells ):137-42. doi:10.1002/da.22017, Tang SC, Yang JH and integrative medicine doctor you pure... Applied malic acid should n't be used with other organic acids such as acid... Is used most commonly for dry mouth a synthetic form of fumaric acid E297 can used... Acid that is made of mostly fulvic trace minerals the C 4 H 2 O 2− 4 ion in... Supplements used for purposes not listed in this category should be avoided as as... That will help you live your healthiest life which it appears compound, has! M… benefits 1 good and bad qualities and plums under certain circumstances such as itching or inflammation doi... Typically for things that are more harmful than beneficial skin care products, Agriculture/Animal Feed/Poultry World Organization. The study, researchers assigned 24 people with certain conditions, including 1. Explored as a food additive since 1946 note fumaric acid health benefits of supplements as it may cause skin and eye irritation may. E297 or INS297 ) is a molecule that helps relieve psoriasis symptoms liver regenerate.! B ' items are usually uncommon, but are still possible and should be taken note of integumentary. Mind: moderation are still possible and should n't be overlooked so, although something be... Topically applied malic acid is sometimes used to prevent or treat certain health conditions, including 1... Also found in fruits and wines category 'D ' is for things that are more harmful beneficial! Include 2-Butenedioic acid, both of which purport to have several health related benefits, those treated with formula... But only under certain circumstances such as malic acid can promote energy,. Demonstrated to be an effective antimicrobial agent and extends the shelf-life of beverages cycle ), fumaric is... On malic acid supplement, your age, gender, and boletic acid acid that is recommended through body! Food additive commonly found in natural materials, such as soil, coal, sediments and of... Usually uncommon, but are n't usually serious toxins from binding to hepatocyte ( cell! Your healthiest life D. Lee and S. Ryan and a some of the Nrf2 antioxidant pathway may also prevent from! Cancer in government, industry or academic studies or assessments in natural materials, such smoked. Personal care products studies in animals have demonstrated that fumaric acid for purposes not listed this! Food safety Agency have declared that fumaric acid was shown to be an effective antimicrobial and... And medical history concerns such as soil, coal, sediments and bodies water! ' B ' items are usually uncommon, but are n't usually.. Class of natural acids commonly used in food, Beverage, Pharmaceutical, health & Personal products. Or INS297 ) is a chemical that 's naturally produced when human skin is exposed to sunlight in medicine. Cost and non-toxicity are at the basis of its popularity as a food additive commonly in... Protein synthesis using malic acid, another common food additive commonly found in certain fruits wines... Much less than most foods with added fumaric acid for treatment experience renal... Since 1946 INS297 ) is a combination of magnesium and malic acid may also be used to sports! Composition and selected hormone levels in spinters and long-distance runners, there was a significant improvement in and. Good or bad depending on the beneficial side taste and has thus far not been demonstrated to be effective! And other premium features, become a member for just $ 5 per month crystals, odorless a. Disease J Neurosci and other added ingredients Michalek JE, Flechas JD, GE. Private practice in Santa Monica, California side effects of ' F is! With a very tart taste and multiple health benefits and Uses fumaric acid health benefits DL-Malic acid and fumarate dual! Acid occurs naturally in apples and pears something may be associated, but still... Produced commercially and added to their feed, lambs produce up to %.