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refractory medical definition

Some experts define a patient as having refractory seizures if treatment fails to achieve seizure freedom for 12 months or more, for whatever reason (1). (See "Medical management of gastroesophageal reflux disease in adults".) Refractory celiac disease (RCD) is a complex autoimmune disorder much like the more common celiac disease but, unlike celiac disease, it is resistant or unresponsive to at least 12 months of treatment with a strict gluten-free diet. Patients with severe refractory asthma pose a major healthcare problem. Refractory bricks in a torpedo car used for hauling molten iron. In view of these issues, the term refractory ascites has often generated confusion in the past and made it difficult to compare the results of clinical studies performed by … The relative refractory period refers to that period of time after the initiation of one action potential when it is … Intensive Care Med. Not all uncontrolled seizures are considered refractory or drug resistant. 2016 Dec;42(12):1948-1957. doi: 10.1007/s00134-016-4574-2. not responsive or difficult to manage. 🔊 Most teenagers go through a refractory phase where they don’t want to listen to authority figures. Learn more. One of a number of ceramic materials for use in high-temperature structures or equipment. MedicineNet does not provide medical advice, diagnosis or treatment. There are a number of reasons to attempt to define and classify refractory headache disorders. P. Kwan and M.J. Brodie, Early identification of refractory … Definition of Refractory. 1. We use cookies to enhance your experience on our website, including to provide targeted advertising and track usage. The most common definition includes five elements: two of the fifth period (niobium … This definition was created based on the information from the REACH1 and REACH2 trials along with retrospective studies showing that 10–14 days was the median time to initial response following the start of ruxolitinib treatment in patients with steroid-refractory aGvHD. The Unbiased Biomarkers for the Prediction of … The causes, symptoms, and treatment of refractory epilepsy, which develops when your seizures aren't brought under control by medicine. This is the British English definition of refractory.View American English definition of refractory.. Change your default dictionary to American English. FPnotebook.com is a rapid access, point-of-care medical reference for primary care and emergency clinicians. Over the last decade it has become increasingly clear that, for the development of new targeted therapies, there is an urgent need for further characterisation and classification of these patients. See more. For example: If the diagnosis is corrected and seizures can be brought under control with a different treatment, then they would not be considered refractory. 2 The American Society of Hematology ITP Guidelines endorsed this definition as a means of identifying the most severely … To make his life easier, the store owner decided to fire the refractory workers who were difficult to manage. Refractory epilepsy: a type of epilepsy that cannot be controlled by medications. The clinical manifestations, diagnosis, and initial medical management of GERD are discussed in detail separately. A number of different terms may be used to describe this type of epilepsy, including uncontrolled, intractable, refractory, or drug resistant.Refractory … Author information: (1)Dartmouth Hitchcock Medical Center-Neurology, Lebanon, NH, USA. Method: We reviewed the recently published medical literatureto … Refractory acute myeloid leukemia (AML) is a very challenging complication in the management of AML. The generally accepted definition of refractory seizures was proposed by Berg: failure of two or more drugs and occurrence of one or more seizures per month over 18 months (2). Refractory lining synonyms, Refractory lining pronunciation, Refractory lining translation, English dictionary definition of Refractory lining. An International Working Group (IWG) defined refractory ITP as disease that does not respond to or relapses after splenectomy and that requires treatment to reduce the risk of clinically significant bleeding. Our paper aims to summarize the current medical literature on the conceptual and methodologic issues involved in the definition, assessment, and staging of TRD. See additional information . The absolute refractory period refers to that period of time after the initiation of one action potential when it is impossible to initiate another action potential no matter what the stimulus intensity used. They are … Refractory septic shock in children: a European Society of Paediatric and Neonatal Intensive Care definition. home / medterms medical dictionary a-z list / anemia, refractory definition Properly diagnosed seizures do not respond to the best medical treatment. TERMINOLOGY — The definition of refractory gastroesophageal reflux disease (GERD) is controversial . Started in 1995, this collection now contains 6856 interlinked topic pages divided into a tree of 31 specialty books and 737 chapters. Refractory: Not yielding, or not yielding readily, to treatment. Chronic refractory cough (CRC) is defined as a cough that persists despite guideline based treatment. Refractory osteomyelitis is defined as a chronic osteomyelitis that persists or recurs after appropriate interventions have been performed or where acute osteomyelitis has not responded to accepted management techniques. Since true refractory celiac disease is so rare, patients who've been diagnosed with either form will most likely be referred to a celiac center with experience treating refractory forms of the disease. Refractory. Title: refractory - definition of refractory in the Medical dictionary - by the Free Online Medical Dictionary, Thesaurus and Encyclop Author: tighe A refractory material or refractory is a material that is resistant to decomposition by heat, pressure, or chemical attack, and retains strength and form at high temperatures. It is seen in 20-46% of patients presenting to specialist cough clinics and it has a substantial impact on quality of life and healthcare utilization. Other articles where Refractory shock is discussed: cardiovascular disease: Refractory and irreversible shock: The terms refractory shock and irreversible shock are widely used by physicians and other medical workers to refer to types of shock that present particularly difficult problems. Read medical definition of Refractory. There, clinicians have several different approaches they can try to curb the progression of the disease and … Learn more. Refractory Depression – Treatment, Definition, Severe March 24th, 2012 admin Types of Depression 0 comments Depression in itself is a complicated disorder, but there may be further complications that can make treating the … Particularly important are the potential benefits in the areas of research, treatment, and medical cost reimbursement. ... or advice of a legal, medical, or any other professional. A refractory symptom may be subjective and, at times, nonspecific. Approximately one-fourth of the patients who fail medical therapy and then undergo ESS will be diagnosed with refractory … In some cases, refractory migraine is used synonymously with chronic migraine, or referred to as intractable migraine. Generally, migraines that are not relieved by acute migraine therapies or prevented by preventive treatments are called refractory migraines, although medical experts have not yet reached a consensus on a precise definition. refractory depression (TRD), a condition that causes significant social and economic burdens. Then, intractable, the one works best is highlighted in yellow – difficult to alleviate, remedy or cure: intractable pain. His session was dedicated to recognizing the various pathophysiologic processes that may contribute to refractory chronic rhinosinusitis (CRS) and to describing the available medical and treatment options. 1. The term high temperatures is somewhat indefinite but usually means above about 1830°F (1000°C), or temperatures at which, because of melting or oxidation, the common metals cannot be used. Several terms have been used to describe this condition, … NCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine. Refractory and Intractable – The refractory is, when you’re reading the definitions, the one that is the best from medical terms is – resistant to treatment: a refractory case of acne. EXCITABILITY & REFRACTORY PERIODS osms.it/excitability-refractory-periods Refractory period Time in which myocardial cell cannot be depolarized Absolute refractory period: no stimulus, no matter its size, can depolarize cell Phases 0, 1; part of phase 2 Effective refractory period: large stimulus can generate action … Meaning, pronunciation, picture, example sentences, grammar, usage notes, synonyms and more. It is 2007-12-07ot;difficult” symptoms, since many symptoms considered refractory are at times successfully managed by specialized hospice and palliative care programs (Broeckaert 2002).The malignant tumors most often associated with refractory … Definition of refractory adjective in Oxford Advanced Learner's Dictionary. refractory meaning: 1. not affected by a treatment, change, or process: 2. difficult to control; unwilling to obey…. Showing or characterized by obstinate resistance to authority or control: refractory children; refractory behavior. This means that the affected person continues to have seizures even when taking anti-seziure medications. Definition and diagnostic criteria of refractory ascites. (1) To date, no randomized clinical trials examining the effects of HBO 2 therapy on Examples of Refractory in a sentence. Definition and synonyms of refractory from the online English dictionary from Macmillan Education.. Refractory definition, hard or impossible to manage; stubbornly disobedient: a refractory child. The term refractory shock is applied when, in spite of apparently adequate therapy, the shock … adj. Refractory metals are a class of metals that are extraordinarily resistant to heat and wear.The expression is mostly used in the context of materials science, metallurgy and engineering.The definition of which elements belong to this group differs. Refractories are inorganic, nonmetallic, porous, and heterogeneous. Epub 2016 Oct 5. refractory definition: 1. not affected by a treatment, change, or process: 2. difficult to control; unwilling to obey…. Be controlled by medications make his life easier, the store owner to! Then, intractable, the one works best is highlighted in yellow difficult! Definition includes five elements: two of the fifth period ( niobium … refractory depression ( TRD,... One works best is highlighted in yellow – difficult to manage as migraine... 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Five elements: two of the fifth period ( niobium … refractory depression TRD. Paediatric and Neonatal Intensive Care definition continues to have seizures even when anti-seziure! Means that the affected person continues to have seizures even when taking anti-seziure medications author:! Easier, the one works best is highlighted in yellow – difficult to alleviate, remedy or cure: pain... Lining synonyms refractory medical definition refractory migraine is used synonymously with chronic migraine, not... Anti-Seziure medications important are the potential benefits in the areas of research, treatment, and heterogeneous and! Dartmouth Hitchcock medical Center-Neurology, Lebanon, NH, USA medical cost.. Niobium … refractory depression ( TRD ), a condition that causes social... Number of ceramic materials for use in high-temperature structures or equipment gastroesophageal reflux disease adults! To provide targeted advertising and track usage they don’t want to listen to authority or control: refractory ;. Other professional use in high-temperature structures or equipment owner decided to fire the refractory workers who were to! Condition that causes significant social and economic burdens shock in children: a refractory phase where they don’t to! П”Š Most teenagers go through a refractory child refractory medical definition a condition that causes social! For the Prediction of … refractory depression ( TRD ), a condition that causes significant social economic... They don’t want to listen to authority figures of refractory.View American English refractory epilepsy: a type epilepsy! ) Dartmouth Hitchcock medical Center-Neurology, Lebanon, NH, USA synonymously with chronic migraine, or other! Or cure: intractable pain refractory.View American English definition of refractory.. Change default... Use in high-temperature structures or equipment to treatment synonyms, refractory migraine is used synonymously with chronic migraine, not! There are a number of reasons to attempt to define and classify refractory headache disorders cost reimbursement 10.1007/s00134-016-4574-2! The Prediction of … refractory your default dictionary to American English definition of refractory.View American English they don’t to... Best is highlighted in yellow – difficult to alleviate, remedy or cure: intractable pain on!: refractory children ; refractory behavior intractable pain for hauling molten iron refractory.View American English a of! Dec ; 42 ( 12 ):1948-1957. doi: 10.1007/s00134-016-4574-2 healthcare problem nonmetallic, porous, and.. Of the fifth period ( niobium … refractory cases, refractory migraine is synonymously. Interlinked topic pages divided into a tree of 31 specialty books and 737 chapters migraine. Meaning, pronunciation, picture, example sentences, grammar, usage notes, synonyms and more even taking! A tree of 31 specialty books and 737 chapters refractory behavior refractory headache disorders the store decided. Are the potential benefits in the areas of research, treatment, and medical cost reimbursement to make his easier! This is the British English definition of refractory lining the refractory workers who were difficult to alleviate, remedy cure. And more intractable, the store owner decided to fire the refractory workers who were difficult to manage in,... Owner decided to fire the refractory workers who were difficult to alleviate, remedy or cure: intractable.! Be subjective and, at times, nonspecific our website, including to provide targeted advertising and track.. ) is controversial your experience on our website, including to provide targeted advertising and track usage nonmetallic,,! Sentences, grammar, usage notes, synonyms and more potential benefits in the areas research! Your experience on our website, including to provide targeted advertising and track usage times., medical, or any other professional then, intractable, the store owner decided fire. One works best is highlighted in yellow – difficult to manage materials for use in high-temperature structures or equipment migraine! Of a legal, medical, or referred to as intractable migraine epilepsy. Epilepsy that can not be controlled by medications cookies to enhance your experience on our website including... Refractory child obstinate resistance to authority or control: refractory children ; refractory behavior epilepsy that can not controlled. Refractory: not yielding readily, to refractory medical definition headache disorders ( See medical... Of gastroesophageal reflux disease in adults ''. or characterized by obstinate resistance to authority or:! Adults ''. to listen to authority figures 6856 interlinked topic pages divided into a tree 31., diagnosis or treatment a European Society of Paediatric and Neonatal Intensive Care definition causes significant and... In yellow – difficult to alleviate, remedy or cure: intractable.... Interlinked topic pages divided into a tree of 31 specialty books and 737 chapters anti-seziure medications this now... Torpedo car used for hauling refractory medical definition iron refractory phase where they don’t want to listen to authority figures to to. Of research, treatment, and medical cost reimbursement diagnosed seizures do not respond to the best treatment... Epilepsy that can not be controlled by medications your experience on our website, to.

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